Zebrafish patient-derived xenograft models predict lymph node involvement and treatment outcome in non-small cell lung cancer.

Zaheer AliMalin VildevallGabriela Vazquez RodriguezDecky TandionoIoannis VamvakarisGeorgios EvangelouGeorgios LolasKonstantinos N SyrigosAlberto VillanuevaMichael WickShenga OmarAnna ErkstamJulia SchuelerAnna FahlgrenLasse D Jensen

Published in: Journal of experimental & clinical cancer research : CR (2022)

We conclude that the ZTX platform provide a fast, accurate, and clinically relevant system for evaluation of treatment outcome and invasion/dissemination of PDX models, providing an attractive platform for combined mouse-zebrafish PDX trials and personalized medicine.

Keyphrases

lymph node
high throughput
neoadjuvant chemotherapy
high resolution
squamous cell carcinoma
sentinel lymph node
radiation therapy