Investigating the trans-membrane transport of HAIYPRH peptide-decorated nano-drugs.

Xiaowan ZhangMeirong ShanSiying LiJing ZhaoXuelei PangGuocheng YangYuping Shan

Published in: Physical chemistry chemical physics : PCCP (2023)

Transferrin (Tf) has been effectively used to promote the cellular uptake of HAIYPRH (T7) peptide-conjugated nano-drugs. In this study, the enhancing effect of Tf on T7-decorated nano-drug transport was investigated using force tracing and nano-indentation techniques at a single-particle/cell level. Furthermore, the results were confirmed by ensemble fluorescence imaging.

Keyphrases

fluorescence imaging
photodynamic therapy
quantum dots
reduced graphene oxide
single cell
stem cells
single molecule
mass spectrometry
convolutional neural network
gold nanoparticles
high resolution