Harnessing Transcriptomic Signals for Amyotrophic Lateral Sclerosis to Identify Novel Drugs and Enhance Risk Prediction.

Oliver PainAshley JonesAhmad Al KhleifatDevika AgarwalDzmitry HramykaHajer KarouiJędrzej KubicaDavid J LlewellynJanice M RansonZhi YaoAlfredo IacoangeliAmmar Al Chalabi

Published in: medRxiv : the preprint server for health sciences (2023)

Functionally-informed analyses of ALS GWAS summary statistics identified novel mechanistic insights into ALS aetiology, highlighted several therapeutic research avenues, and enabled statistically significant prediction of ALS risk.

Keyphrases

amyotrophic lateral sclerosis
single cell
big data
rna seq
drug induced
genome wide association study