Transcranial Blood-Brain Barrier Opening in Alzheimer's Disease Patients Using a Portable Focused Ultrasound System with Real-Time 2-D Cavitation Mapping.
Sua BaeKeyu LiuAntonios N PouliopoulosRobin JiSergio Jiménez-GambínOmid YousefianAlina R Kline-SchoderAlec J BattsFotios N TsitsosDanae KokossisAkiva MintzLawrence S HonigElisa E KonofagouPublished in: medRxiv : the preprint server for health sciences (2024)
We showed the safety and feasibility of this cost-effective and time-efficient portable NgFUS treatment for BBBO in AD patients with the first demonstration of real-time 2-D cavitation mapping. The cavitation dose correlated with BBBO volume, a slowed increase in pathology, and serum detection of AD proteins. Our study highlights the potential for accessible FUS treatment in AD, with or without drug delivery.