Activation of Notch3 in Renal Tubular Cells Leads to Progressive Cystic Kidney Disease.

Sonja DjudjajPanagiotis KavvadasNiki PrakouraRoman D BülowTiffany MigeonSandrine PlacierChristos E ChadjichristosPeter BoorChristos Chatziantoniou

Published in: International journal of molecular sciences (2022)

In summary, Notch3 signaling promoted tubular cell proliferation, the alignment of cell division, dedifferentiation and hyperplasia, leading to cystic kidney diseases and pre-neoplastic lesions.

Keyphrases

cell proliferation
induced apoptosis
cell cycle arrest
multiple sclerosis
single cell
high glucose
cell therapy
pi k akt
cell cycle
stem cells
oxidative stress
signaling pathway
endothelial cells
cell death
bone marrow