RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery.

Nathan D PennockSonali JindalWesley HortonDuanchen SunJayasri NarasimhanLucia CarboneSuzanne S FeiRobert SearlesChristina A HarringtonJulja BurchardSheila WeinmannPepper J SchedinZheng Xia

Published in: BMC medical genomics (2019)

Our results, which outline a robust FFPE-RNA-seq pipeline for broad use, support utilizing FFPE tissues to address key questions in the breast cancer field, including the delineation between indolent and life-threatening disease, biological stratification and molecular mechanisms of treatment resistance.

Keyphrases

rna seq
single cell
high throughput
small molecule
gene expression
hodgkin lymphoma
smoking cessation