Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis.
Petri EloXiang-Guo LiHeidi LiljenbäckMaria GardbergOlli MoisioMaxwell MinerJenni VirtaAntti SarasteMadduri SrinivasaraoMichael PughPhilip S LowJuhani KnuutiSirpa JalkanenLaura AirasYingjuan June LuAnne RoivainenPublished in: Journal of neuroinflammation (2021)
EC2319 was well tolerated and attenuated inflammation and lesion development in a rat model of a chronic progressive form of MS. Human MS patients have FR-β-positive cells in chronically active plaques, which suggests that these results may have translational relevance.