Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin study.
Jori TomassenAnouk den BraberSophie M van der LandenElles KonijnenbergCharlotte E TeunissenLisa VermuntEco J C de GeusDorret I BoomsmaPhilip ScheltensBetty M TijmsPieter Jelle VisserPublished in: Alzheimer's & dementia (New York, N. Y.) (2022)
These results suggest that memory and language decline are early features of AD that are in part determined by the same genetic factors that influence amyloid-β and tau regulation.