IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment.

Jun ZhangLingfeng FuNoriko Yasuda-YoshiharaAtsuko YonemuraFeng WeiLuke BuXichen HuTakahiko AkiyamaFumimasa KitamuraTadahito YasudaTakashi SembaTomoyuki UchiharaRumi ItoyamaKohei YamashitaKojiro EtoShiro IwagamiMasakazu YashiroYoshihiro KomoharaHideo Baba Takatsugu Ishimoto

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2022)

These findings demonstrated that mixed-polarized macrophages exist as a novel subtype through the reciprocal interaction between DGC cells and nonmalignant cells.

Keyphrases

induced apoptosis
cell cycle arrest
stem cells
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell death