Enantioselective Total Synthesis of (+)-Alterbrassicicene C.
Noah J SimsWeston C BonnetDanielle M LawsonJohn L WoodPublished in: Journal of the American Chemical Society (2022)
Herein, the first total synthesis of (+)-alterbrassicicene C ( 2 ) is described. Key features of the synthesis include an oxiranium mediated ether ring expansion, an oxa-Michael/retro-oxa-Michael cascade, and installation of a vinyl methoxy ether moiety via Stille coupling.