Total Syntheses of Periconiasins A-E.
Chong TianXiaoqiang LeiYuanhao WangZhen DongGang LiuYefeng TangPublished in: Angewandte Chemie (International ed. in English) (2016)
The first and collective total syntheses of periconiasins A-E, a group of naturally occurring cytochalasans, were achieved by a series of rationally designed or bioinspired transformations. Salient features of the syntheses include a tandem aldol condensation/Grob fragmentation to assemble the linear polyketide-amino acid hybrid precursor, a Diels-Alder macrocylization to construct the 9/6/5 tricyclic core of periconiasins A-C, and a transannular carbonyl-ene reaction to forge the polycyclic framework of periconiasins D and E.
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