Intraplatelet miRNA-126 regulates thrombosis and its reduction contributes to platelet inhibition.

Lu-Jun ZhangYang-Xi HuRong-Zhong HuangYan-Yan XuShao-Hua DongFang-Hao GuoJun-Jun GuoJing-Jing QiuZi-Yun CaoLi-Jiang WeiJia-Hao MaoAnkang LyuJun-Ling LiuXian-Xian ZhaoZhi-Fu GuoQing Jing

Published in: Cardiovascular research (2024)

Our murine and human data reveal that (i) intraplatelet miR-126 contributes to platelet activity and promotes thrombus formation, and (ii) the reduction of intraplatelet miR-126 contributes to platelet inhibition during antiplatelet therapy.

Keyphrases

antiplatelet therapy
cell proliferation
long non coding rna
acute coronary syndrome
percutaneous coronary intervention
long noncoding rna
endothelial cells
pulmonary embolism
electronic health record
genome wide
gene expression
big data
machine learning
data analysis