Polymorphism rs368234815 of interferon lambda 4 gene and spontaneous clearance of hepatitis C virus in haemodialysis patients: a case-control study.
Alicja E GrzegorzewskaAdrianna MostowskaMonika K ŚwiderskaWojciech MarcinkowskiIreneusz StolarekMarek FiglerowiczPaweł P JagodzińskiPublished in: BMC infectious diseases (2021)
In haemodialysis patients, the association of rs368234815 with the spontaneous HCV clearance is better than that documented for other IFNL3/IFNL4 polymorphisms only in the additive mode of inheritance. However, identifying the homozygosity in the variant ∆G allele of rs368234815 means a more potent prediction of persistent HCV infection in haemodialysis subjects that we observe in the case of the variant homozygosity of other tested IFNL3/IFNL4 polymorphisms. Removal of PLAGL1 TFBS in subjects harbouring the rs368234815 ∆G allele may contribute to cancer susceptibility. The association of rs368234815 with cancer-related mortality needs further studies in HCV-exposed subjects.
Keyphrases
- hepatitis c virus
- end stage renal disease
- chronic kidney disease
- peritoneal dialysis
- newly diagnosed
- human immunodeficiency virus
- prognostic factors
- type diabetes
- squamous cell carcinoma
- coronary artery disease
- cardiovascular events
- patient reported outcomes
- gene expression
- dna methylation
- risk factors
- immune response
- anti inflammatory
- patient reported
- hiv infected
- mitochondrial dna
- antiretroviral therapy