RNA in situ hybridization for human papillomavirus testing in oropharyngeal squamous cell carcinoma on a routine clinical diagnostic platform.

Rhonda Henley-SmithAlice SantambrogioCynthia L AndoniadouEdward OdellSelvam Thavaraj

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2020)

Human papillomavirus testing by standalone automated RNA in situ hybridization on a clinical diagnostic platform currently available in routine diagnostic histopathology laboratories is a feasible alternative to the two-step algorithm of p16 and DNA in situ hybridization. Control tissue staining procedures need to be adapted to achieve the most accurate results.

Keyphrases

squamous cell carcinoma
high throughput
machine learning
deep learning
clinical practice
nucleic acid
high resolution
single cell