Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease.

Min Seok BaekHanna ChoHye Sun LeeJae Hoon LeeYoung Hoon RyuChul Hyoung Lyoo

Published in: Alzheimer's research & therapy (2020)

Progressive tau accumulation may be more prominent in ε4 carriers, particularly in the medial and lateral temporal cortices. ApoE ε4 allele has differential effects on the Aβ burden depending on the existing amyloidosis and may enhance vulnerability to progressive tau accumulation in the AD spectrum independent of Aβ.

Keyphrases

cognitive decline
cerebrospinal fluid
multiple sclerosis
high fat diet
climate change
mild cognitive impairment
minimally invasive
adipose tissue
type diabetes
metabolic syndrome
insulin resistance