Fetal central nervous system anomalies according to RT-PCR and trimester of maternal infection with Zika virus: A prospective cohort study.
Luz Ángela Gutiérrez SánchezCarlos Hernán Becerra-MojicaMario Augusto RojasLuis Alfonso Díaz-MartínezLuis Alfonso PérezGustavo Adolfo Contreras GarcíaLuz Stella Pinilla GarcíaPublished in: Acta obstetricia et gynecologica Scandinavica (2021)
The prevalence of fetal CNS anomalies was higher than previously reported in the literature for both symptomatic RT-PCR-positive and -negative pregnant women. Corpus callosum anomalies, microcephaly, neuronal migration disorders, and brain parenchymal hyperechogenicities were the most frequent CNS anomalies detected. In addition, CNS anomalies were more frequent and severe in infected fetuses during the first trimester of pregnancy than during the second or third trimester.