The peripheral dopamine 2 receptor antagonist domperidone attenuates ethanol enhancement of dopamine levels in the nucleus accumbens.
James Daniel ObrayEun Young JangAnneke M KlompChristina A SmallAaron P RichardsonJoshua J LeBaronJin Gyeom LeeJordan T YorgasonChae Ha YangScott C SteffensenPublished in: Alcoholism, clinical and experimental research (2022)
These results show that peripheral dopamine 2 receptors mediate some of the effects of ethanol on nonphysiological dopamine neurotransmission, although these effects are not related to the rewarding properties of ethanol.