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Modelling the optimal dosing schedule for artemether-lumefantrine chemoprophylaxis against malaria.

Joel TarningLorenz von SeidleinArjen M DondorpNicholas J WhiteRichard James Maude
Published in: BMC research notes (2022)
A full 3 day AL treatment course given twice a month, and twice daily treatment given once a week, resulted in trough concentrations consistently above the therapeutic threshold of 200 ng/mL. However, the most favourable exposure profile, and arguably most practical dosing scenario, was an initial 3 day full AL treatment course followed by twice daily dosing given once a week for the duration of chemoprevention. The latter was adopted as the dosing schedule for the trial.
Keyphrases
  • clinical trial
  • physical activity
  • study protocol
  • plasmodium falciparum