Characterization and modulation of the pro-inflammatory effects of immune cells in the canine intervertebral disk.

Mary K HeimannKelly ThompsonGilian GunschShirley N TangBrett KlamerKara CorpsBenjamin A WalterSarah A MooreDevina Purmessur

Published in: JOR spine (2024)

There is increased MC, MØs, and vascular ingrowth in the degenerate canine IVD tissue, similar to observations in the clinical population with IVDD and LBP. MCs co-cultured with canine NP cells drive inflammation, and CS and PAR2A are potential therapeutics that may mitigate the pathophysiology of IVDD in vitro.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
endothelial cells
cell death
climate change