ST-elevated myocardial infarction (STEMI) patients exhibit high levels of plasma double-stranded DNA (dsDNA), which directly potentiates platelet activation through the platelet cGAS/STING/NLRP3/caspase-1/IL-1β signaling pathway. STEMI patients may benefit from cGAS inhibition in the prevention of platelet hyperactivity and thrombus formation.
Keyphrases
- end stage renal disease
- signaling pathway
- chronic kidney disease
- ejection fraction
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- cell death
- single molecule
- st segment elevation myocardial infarction
- binding protein
- oxidative stress
- escherichia coli
- coronary artery disease
- induced apoptosis
- patient reported
- endoplasmic reticulum stress