CYP3A5 genotype and its impact on vincristine pharmacokinetics and development of neuropathy in Kenyan children with cancer.

Jodi L SkilesChienWei ChiangClaire H LiSteve MartinEllen L SmithGilbert OlbaraDavid R JonesTerry A VikSaskia MostertFloor AbbinkGertjan J KaspersLang LiFestus NjugunaTammy J SajdykJamie L Renbarger

Published in: Pediatric blood & cancer (2017)

Genetic factors are associated with VCR PK. Due to the minimal neuropathy observed in this cohort, there was no demonstrable association between genetic factors or VCR PK with development of VIPN. Further studies are needed to determine the role of genetic factors in optimizing dosing of VCR for maximal benefit.

Keyphrases

genome wide
copy number
young adults
papillary thyroid
heart rate
dna methylation
blood pressure
squamous cell