Targeting Treg-expressed STAT3 enhances NK-mediated surveillance of metastasis and improves therapeutic response in pancreatic adenocarcinoma.
Miles PiperBenjamin Van CourtAdam C MuellerShuichi WatanabeThomas E BickettShilpa BhatiaLaurel B DarraghMaxwell MayedaDiemmy NguyenJacob GadwaMichael William KnitzSophia CorboRustain L MorganJung-Jae LeeAlexander DentKaryn GoodmanWells MessersmithRichard SchulickMarco Del ChiaroYuwen ZhuRoss M KedlLaurel L LenzSana D KaramPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Our results suggest targeting Treg-mediated immunosuppression is a critical step in mediating a response to treatment and identify NK cells as not only a prognostic marker of improved survival, but also as an effector population that functions to combat metastasis.