Dysregulation of the Adaptive Immune System in Patients With Early-Stage Parkinson Disease.
Zhaoqi YanWei YangHairong WeiMarissa N DeanDavid G StandaertGary R CutterEtty N BenvenisteHongwei QinPublished in: Neurology(R) neuroimmunology & neuroinflammation (2021)
These findings suggest that alterations in the adaptive immune system may promote clinical disease in PD by skewing to a more proinflammatory state in the early-stage PD patient cohort. Our study may shed light on potential immunotherapies targeting dysregulated CD4+ T cells, CD8+ T cells, and CD19+ B cells in patients with PD.