Acute kidney injury during pregnancy leads to increased sFlt-1 and sEng and decreased renal T regulatory cells in pregnant rats with HELLP syndrome.

Jamie SzczepanskiShauna-Kay SpencerAshley GriffinTeylor BowlesJan Michael WilliamsPatrick B KyleJohn Polk DumasSarah ArajiKedra Wallace

Published in: Biology of sex differences (2020)

The findings in this study suggest that AKI during pregnancy contributes to increased blood pressure and biochemical markers for HELLP syndrome, creates an anti-angiogenic imbalance, and exacerbates kidney injury as shown on histopathology, GFR, and kidney injury markers.

Keyphrases

acute kidney injury
blood pressure
induced apoptosis
cardiac surgery
case report
pregnant women
transcription factor
metabolic syndrome
hypertensive patients
type diabetes
oxidative stress
endoplasmic reticulum stress