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Incorporating single-arm studies in meta-analysis of randomised controlled trials: a simulation study.

Janharpreet SinghKeith R AbramsSylwia Bujkiewicz
Published in: BMC medical research methodology (2021)
The hierarchical power and commensurate prior methods provide the most robust approach to synthesising aggregate data from RCTs and single-arm studies, balancing the need to account for bias and differences in between-study heterogeneity, whilst reducing uncertainty in estimates. This work was restricted to considering a pairwise meta-analysis using aggregate data.
Keyphrases
  • case control
  • systematic review
  • electronic health record
  • big data
  • meta analyses
  • machine learning
  • artificial intelligence
  • deep learning