Brain metastases of the mucoepidermoid lung carcinoma: a case report.
Damir TomacIvan KonstantinovićČedna Tomasović-LončarićJurica MarakovićAnđelo KaštelančićDarko OreškovićDominik RomićPetar MarčinkovićMarina RaguzDarko ChudyTonko MarinovićPublished in: Journal of surgical case reports (2024)
Mucoepidermoid carcinoma, a salivary gland tumor, rarely occurs in bronchial mucous glands. Brain metastases are rarely seen which makes for a challenging diagnosis and treatment approach. A 40-year-old woman presented with confusion, and ataxia, accompanied by a declining Glasgow Coma Score. Brain computerized tomography revealed two hyperdense, postcontrast-enhanced infra- and supratentorial lesions with perifocal edema. First causing obstructive hydrocephalus. The initial surgery involved external ventricular drainage system placement leading to the patient's clinical improvement. After radiological diagnostics, both lesions were resected without complications. Histopathological analysis revealed solid clusters of atypical, polygonal epithelial cells exhibiting mucin production, classified as a poorly differentiated mucoepidermoid carcinoma metastasis which originated from the upper lobe's apicoposterior segment and left lung. The correct treatment approach remains elusive due to the infrequent occurrence and challenging diagnosis. While new oncological and radiosurgery options promise improved overall survival rates, radical resection remains the preferred initial option.
Keyphrases
- brain metastases
- small cell lung cancer
- ultrasound guided
- minimally invasive
- heart failure
- single cell
- risk assessment
- lymph node
- case report
- left ventricular
- multiple sclerosis
- cerebrospinal fluid
- big data
- clinical decision support
- deep learning
- surgical site infection
- combination therapy
- replacement therapy
- blood brain barrier
- cerebral ischemia
- artificial intelligence