PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139.
Wissam BeainoBieneke JanssenEsther KooijmanRicardo VosRobert C SchuitJames O'Brien-BrownMichael KassiouBert van Het HofDanielle J VugtsHelga E de VriesAlbert D WindhorstPublished in: Journal of neuroinflammation (2020)
Our data shows that [11C]SMW139 is a promising PET tracer for imaging neuroinflammation and evaluating the dynamics of pro-inflammatory microglia in the brain. This can provide crucial insights into the role of microglia in disease progression and enables the development of novel treatment strategies aimed at modulating the immune response in order to promote neuroprotection.
Keyphrases
- pet imaging
- multiple sclerosis
- cerebral ischemia
- immune response
- inflammatory response
- white matter
- positron emission tomography
- neuropathic pain
- lipopolysaccharide induced
- lps induced
- high resolution
- subarachnoid hemorrhage
- brain injury
- resting state
- blood brain barrier
- traumatic brain injury
- toll like receptor
- signaling pathway
- computed tomography
- dendritic cells
- cognitive impairment
- spinal cord
- pet ct
- functional connectivity
- data analysis