Pre-clinical development of a cryopreservable megakaryocytic cell product capable of sustained platelet production in mice.

Ami PatelCara Marie ClementelliDanuta JarochaGohar MosoyanCindy ElseManisha KintaliHelen FongJay TongRonald GordonVirginia GillespieAlla KeyznerMortimer PonczRonald HoffmanCamelia Iancu-Rubin

Published in: Transfusion (2019)

This is a proof-of-principle study demonstrating the creation of a cryopreservable megakaryocytic cell product which releases functional PLTs in vivo. Clinical development of such a product is currently being pursued for the treatment of thrombocytopenia in patients with hematological malignancies.

Keyphrases

single cell
cell therapy
type diabetes
combination therapy
high fat diet induced
replacement therapy
smoking cessation