Effect of Trikafta on bone density, body composition and exercise capacity in CF: A pilot study.
Michal GurRonen Bar-YosephMoneera HannaDana AbboudZohar KeidarTala PalchanYazeed ToukanKamal MasarwehIrit AlishaNehama Zuckerman-LevinLea BenturPublished in: Pediatric pulmonology (2022)
To the best of our knowledge, this is the first study evaluating the metabolic effects of Trikafta. The results are encouraging and offer hope beyond the well-established effect on pulmonary disease. Larger long-term studies are warranted to unpin the underlying physiological mechanisms.