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miR-135b-5p promotes gastric carcinogenesis by targeting CLIP4-mediated JAK2/STAT3 signal pathway.

Zhiwei PengCan FangHaibo YuanYinan ZhuZihao RenMing LuKongwang Hu
Published in: Cellular signalling (2024)
This study reveals a novel mechanism by which miR-135b-5p exerts its tumor-promoting functions by targeting CLIP4. The tumor-suppressive function of CLIP4 by inactivating the JAK2/STAT3 pathway is also elucidated. Regulatory mechanism of CLIP4 by miR-135b-5p provides a promising novel therapeutic strategy for GC patients.
Keyphrases
  • endoscopic submucosal dissection
  • end stage renal disease
  • newly diagnosed
  • chronic kidney disease
  • peritoneal dialysis
  • prognostic factors
  • transcription factor
  • patient reported outcomes