Ticagrelor attenuates the increase of extracellular vesicle concentrations in plasma after acute myocardial infarction compared to clopidogrel.
Aleksandra GaseckaRienk NieuwlandMonika BudnikFrançoise Dignat-GeorgeCeren EyiletenPaul HarrisonRomaric LacroixAurélie LeroyerGrzegorz OpolskiKinga PlutaEdwin van der PolMarek PostulaPia R-M SiljanderJolanta M Siller-MatulaKrzysztof Jerzy FilipiakPublished in: Journal of thrombosis and haemostasis : JTH (2020)
Ticagrelor attenuates the increase of EV concentrations in plasma after acute myocardial infarction compared to clopidogrel. The ongoing release of EVs despite antiplatelet therapy might explain recurrent thrombotic events after AMI and worse clinical outcomes on clopidogrel compared to ticagrelor.