May Previous Hepatitis B Virus Infection Be Involved in Etiology and Pathogenesis of Autoimmune Liver Diseases?

Sergey Batskikh Sergey Morozov Elena Vinnitskaya Evgeniya Sbikina Zanna Borunova Alexey Dorofeev Yulia Sandler Kirill Saliev Dmitry S Kostyushev Sergey Brezgin Anastasiya Kostyusheva Vladimir P Chulanov

Published in: Advances in therapy (2021)

Significant proportions of patients with AILDs are anti-HBc positive, and some of them have OBI. Among patients with AILDs, anti-HBc-positivity is most widespread in the PBC group and in subjects with advanced stage of liver fibrosis. Our data may support the idea of an important role of previous HBV infection in the etiology and pathogenesis of AILDs (namely PBC).

Keyphrases

liver fibrosis
hepatitis b virus
electronic health record
big data
machine learning