Automated enumeration of lymphoid and plasma cells in bone marrow to establish normal reference ranges.

James LiangJacques A J MalherbeKathryn A FullerBob MirzaiCarly GeorgeTina L CarterCatherine H ColeBelinda B GuoKatie L MeehanWendy N Erber

Published in: Journal of clinical pathology (2018)

Combined immunohistochemistry and automated enumeration gives an accurate, reproducible number of antigen-positive cells and has generated normal reference ranges for these cell types in BMT biopsies. The method and ranges we have established have the potential to be applied in routine clinical practice.

Keyphrases

induced apoptosis
clinical practice
bone marrow
cell cycle arrest
machine learning
high throughput
deep learning
circulating tumor cells
single cell
mesenchymal stem cells
endoplasmic reticulum stress
high resolution
oxidative stress
signaling pathway
cell therapy
climate change
cell death