Transcriptional signature associated with early rheumatoid arthritis and healthy individuals at high risk to develop the disease.
N Macías-SeguraJulio Enrique Castañeda-DelgadoY BastianD Santiago-AlgarraJ D Castillo-OrtizA L Alemán-NavarroE Jaime-SánchezM Gomez-MorenoC A Saucedo-ToralEdgar E Lara-RamírezM Zapata-ZuñigaL Enciso-MorenoR González-AmaroC Ramos-RemusJ A Enciso-MorenoPublished in: PloS one (2018)
The presence of a specific transcriptome in whole blood of RA patients suggests the activation of a specific inflammatory transcriptional signature in early RA development. The set of overexpressed genes in early RA patients that are shared with ACCP+ subjects but not with ACCP- subjects, can represent a transcriptional signature involved with the transition of a preclinical to a clinical RA stage. Some of these particular up-regulated and down-regulated genes are related to inflammatory processes and could be considered as biomarker candidates for disease progression in subjects at risk to develop RA.
Keyphrases
- rheumatoid arthritis
- end stage renal disease
- disease activity
- transcription factor
- gene expression
- ejection fraction
- newly diagnosed
- chronic kidney disease
- ankylosing spondylitis
- genome wide
- prognostic factors
- oxidative stress
- peritoneal dialysis
- stem cells
- systemic lupus erythematosus
- dna methylation
- patient reported outcomes
- mesenchymal stem cells
- rna seq
- cell therapy
- heat shock protein
- genome wide analysis