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A photoswitchable GABA receptor channel blocker.

Galyna MaleevaDaniel WutzKarin RustlerAlba Nin-HillCarme RoviraElena PetukhovaAntoni Bautista-BarrufetAlexandre Gomila-JuanedaPetra ScholzeFranck PeirettiMercedes Alfonso-PrietoBurkhard KönigPau GorostizaPiotr Bregestovski
Published in: British journal of pharmacology (2019)
Azo-NZ1 is a soluble light-driven Cl-channel blocker, which allows photo-modulation of the activity induced by anion-selective Cys-loop receptors. Azo-NZ1 is able to control GABAergic postsynaptic currents and provides new opportunities to study inhibitory neurotransmission using patterned illumination.
Keyphrases
  • angiotensin converting enzyme
  • transcription factor
  • ionic liquid
  • binding protein