Test-dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non-malignant disorders.

Sharat ChandraKana MizunoJunfang ZhaoStella M DaviesRebecca A MarshTsuyoshi FukudaKenneth D R SetchellAlexander A VinksParinda A Mehta

Published in: British journal of clinical pharmacology (2021)

Melphalan test-dose PK reliably predicts full-dose PK and allows for accurate adjustment of full-dose melphalan in RIC-HCT for NMD. This approach can avoid excess toxicity from increased systemic exposure, especially in patients with organ impairment.

Keyphrases

high dose
stem cell transplantation
bone marrow
oxidative stress
low dose
mass spectrometry