Biomodal Tumor-Targeted and Redox-Responsive Bi2 Se3 Hollow Nanocubes for MSOT/CT Imaging Guided Synergistic Low-Temperature Photothermal Radiotherapy.
Yilin SongYule WangYan ZhuYu ChengYidan WangSiyu WangFengping TanFan LianNan LiPublished in: Advanced healthcare materials (2019)
Hyperthemia (>50 °C) induced heating damage of nearby normal organs and inflammatory diseases are the main challenges for photothermal therapy (PTT) of cancers. To overcome this limitation, a redox-responsive biomodal tumor-targeted nanoplatform is synthesized, which can achieve multispectral optoacoustic tomography/X-ray computed tomography imaging-guided low-temperature photothermal-radio combined therapy (PTT RT). In this study, Bi2 Se3 hollow nanocubes (HNCs) are first fabricated based on a mild cation exchange way and Kirkendall effect and then modified with hyaluronic acid (HA) through redox-cleavable linkage (-s-s-), thus enabling the HNC to target cancer cells overexpressing CD-44 and control the cargo release profile. Finally, gambogic acid (GA), a type of heat-shock protein (HSP) inhibitor, which is vital to cells resisting heating-caused damage is loaded, into Bi2 Se3 HNC. Such HNC-s-s-HA/GA under a mild NIR laser irradiation can induce efficient cancer cell apoptosis, achieving PTT under relatively low temperature (≈43 °C) with remarkable cancer cell damage efficiency. Furthermore, enhanced radiotherapy (RT) can also be experienced without depth limitation based on RT sensitizer Bi2 Se3 HNC. This research designs a facile way to synthesize Bi2 Se3 HNC-s-s-HA/GA possessing theranostic functionality and cancer cells-specific GSH, but also shows a low-temperature PTT RT method to cure tumors in a minimally invasive and highly efficient way.
Keyphrases
- cancer therapy
- highly efficient
- heat shock protein
- drug delivery
- pet ct
- computed tomography
- photodynamic therapy
- oxidative stress
- fluorescence imaging
- high resolution
- hyaluronic acid
- dual energy
- minimally invasive
- early stage
- drug release
- induced apoptosis
- heat shock
- positron emission tomography
- locally advanced
- radiation therapy
- image quality
- diabetic rats
- cell proliferation
- magnetic resonance imaging
- optical coherence tomography
- quantum dots
- bone marrow
- cell therapy
- fluorescent probe
- mesenchymal stem cells
- robot assisted
- heat stress
- dna methylation
- signaling pathway
- stress induced
- replacement therapy