Clinical and Genetic Atrial Fibrillation Risk and Discrimination of Cardioembolic From Noncardioembolic Stroke.

Lu-Chen Wang Shaan Khurshid Sophia Gunn Ludovic Trinquart Kathryn L Lunetta Huichun Xunull nullEmelia J Benjamin Patrick T Ellinor Christopher D Anderson Steven A Lubitz

Published in: Stroke (2023)

Addition of polygenic risk of AF to clinical risk factors modestly improves the discrimination of cardioembolic from noncardioembolic strokes, as well as reclassification of stroke subtype. Polygenic risk of AF may be a useful biomarker for identifying strokes caused by AF.

Keyphrases

atrial fibrillation
oral anticoagulants
left atrial
catheter ablation
left atrial appendage
risk factors
direct oral anticoagulants
heart failure
percutaneous coronary intervention
dna methylation
copy number
left ventricular
mitral valve
cerebral ischemia