The gut microbiome in sickle cell disease: Characterization and potential implications.

Hassan BrimJames TaylorMuneer AbbasKimberly VilmenayMohammad DaremipouranSudhir VarmaEdward LeeBetty PaceWaogwende L Song-NabaKalpna GuptaSergei NekhaiPatricia O'NeilHassan Ashktorab

Published in: PloS one (2021)

A major dysbiosis was observed in SCD patients for bacteria that are known strong pro-inflammatory triggers. The Townes mouse showed dysbiosis as well and might serve as a good model to study gut microbiome modulation and its impact on SCD pathophysiology.

Keyphrases

sickle cell disease
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
climate change