Standardized statistical framework for comparison of biomarkers: Techniques from ADNI.
Danielle J HarveyDuygu TosunClifford R JackMichael WeinerLaurel A Beckettnull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
A framework for comparison of biomarkers on pre-defined criteria is presented. Criteria for comparison include precision in capturing change and clinical validity. Ventricular volume has high precision in change for both dementia and mild cognitive impairment (MCI) trials. Imaging measures' performance in clinical validity varies more for dementia than for MCI.