Bevacizumab induces oxidative cytotoxicity and apoptosis via TRPM2 channel activation in retinal pigment epithelial cells: Protective role of glutathione.
Dilek ÖzkayaMustafa NazıroğluPublished in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2021)
Our data confirmed that BEV-induced mitochondrial ROS and apoptosis in the human retinal epithelial cells were modulated by GSH and TRPM2 inhibition. The treatment of GSH may be considered as a therapeutic approach to BEV-induced ARPE-19 cell injury.
Keyphrases
- oxidative stress
- diabetic rats
- high glucose
- cell death
- endothelial cells
- endoplasmic reticulum stress
- cell cycle arrest
- optical coherence tomography
- drug induced
- single cell
- stem cells
- fluorescent probe
- big data
- machine learning
- reactive oxygen species
- replacement therapy
- deep learning
- bone marrow
- metastatic colorectal cancer
- optic nerve
- pi k akt