Use of a high platelet-to-RBC ratio of 2:1 is more effective in correcting trauma-induced coagulopathy than a ratio of 1:1 in a rat multiple trauma transfusion model.
Derek J B KleinveldMathijs R WirtzDaan P van den BrinkM Adrie W MaasJoris J T H RoelofsJ Carel GoslingsMarkus W HollmannNicole P JuffermansPublished in: Intensive care medicine experimental (2019)
Resuscitation with a high (2:1) PLT-to-RBC ratio was more effective compared to standard (1:1) PLT-to-RBC ratio in treating TIC, with a trend towards reduced transfusion volumes. Also, high PLT dose did not aggravate organ damage. Transfusion strategies using higher PLT dose regiments might be a feasible treatment option in hemorrhaging trauma patients for the correction of TIC.