Enantioselective [3 + 2] Cycloaddition of Vinylcyclopropanes with Alkenyl N -Heteroarenes Enabled by Palladium Catalysis.

The first catalytic enantioselective [3 + 2] cycloaddition reaction between vinylcyclopropanes and alkenyl N -heteroarenes in the presence of LiBr and a Pd(0)/SEGPHOS complex was developed. LiBr plays a key role in improving the reactivity of alkenyl N -heteroarenes as a mild Lewis acid.