Profiling the genome and proteome of metabolic dysfunction-associated steatotic liver disease identifies potential therapeutic targets.
Jun LiuSile HuLingyan ChenCharlotte DalyCesar Augusto Prada MedinaTom G RichardsonMatthew TraylorNiall J DempsterRichard MbasuThomas MonfeugaMarijana VujkovicPhilip S TsaoJulie A LynchBenjamin F VoightKyong-Mi Changnull nullJeremy F CobboldJeremy W TomlinsonCornelia M van DuijnJoanna M M HowsonPublished in: medRxiv : the preprint server for health sciences (2023)
This study identified new protein targets in the causal pathway of MASLD, providing new insights into the multi-omics architecture and pathophysiology of MASLD. These findings advise further therapeutic interventions for MASLD.