Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats.

Ling XieRuonan ZhaiTeng ChenChongting GaoRui XueNiansong WangJianbo WangYouhua XuDing-Kun Gui

Published in: Drug design, development and therapy (2020)

PN ameliorated albuminuria and podocyte EMT in diabetic rats partly through inhibiting Wnt/β-catenin signaling pathway. These findings provide experimental arguments for a novel therapeutic option in DN.

Keyphrases

diabetic rats
oxidative stress
epithelial mesenchymal transition
high glucose
diabetic nephropathy
cell proliferation
stem cells
signaling pathway
mouse model
stress induced