Established pulmonary hypertension in rats was reversed by a combination of a HIF-2α antagonist and a p53 agonist.

Qiuyu ZhengWenju LuHan YanXin DuanYuqin ChenChenting ZhangXiaoyun LuoJiyuan ChenChao WangShiyun LiuYi LiHaiyang TangShamin RahimiShayan RahimiJason X-J YuanNanshan ZhongKai Yang Jian Wang

Published in: British journal of pharmacology (2021)

Combination treatment confers greater therapeutic efficacy against PH through a selective modulation of p53 and HIF-2α in PASMC and PAEC.

Keyphrases

pulmonary hypertension
endothelial cells
pulmonary artery
pulmonary arterial hypertension
combination therapy