CD45 - erythroid progenitor cells promote lymph node metastasis in gastric cancer by inducing a hybrid epithelial/mesenchymal state in lymphatic endothelial cells.

Jing-Yun WenXing LiJian-Ning ChenJie ChenJing-Yue ZhangYu DuWei-Hang ZhuYong-Jian ChenRi-Hong YangChun-Kui Shao

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2023)

EPCs accumulated in GC tissues and metastatic LNs and promoted LN metastasis via the S100A8/9-induced hybrid E/M state of LECs, which was the specific mechanism of LN metastasis in the early stages of GC.

Keyphrases

lymph node metastasis
squamous cell carcinoma
high glucose
endothelial cells
papillary thyroid
small cell lung cancer
stem cells
bone marrow
gene expression
lymph node
gas chromatography
diabetic rats
vascular endothelial growth factor
high resolution
simultaneous determination