Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.

Sharadha SakthikumarAnanya RoyLulu HaseebMats E PetterssonElisabeth SundströmVoichita D MarinescuKerstin Lindblad-TohKarin Forsberg-Nilsson

Published in: Genome biology (2020)

These results suggest that non-coding constraint mutations could play an essential role in GBM, underscoring the need to connect non-coding genomic variation to biological function and disease pathology.

Keyphrases

gene expression
transcription factor