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Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.

Sharadha SakthikumarAnanya RoyLulu HaseebMats E PetterssonElisabeth SundströmVoichita D MarinescuKerstin Lindblad-TohKarin Forsberg-Nilsson
Published in: Genome biology (2020)
These results suggest that non-coding constraint mutations could play an essential role in GBM, underscoring the need to connect non-coding genomic variation to biological function and disease pathology.
Keyphrases
  • gene expression
  • transcription factor