Overexpression of TREM1 is Associated with the Immune-Suppressive Microenvironment and Unfavorable Prognosis in Pan-Cancer.

Xin-Wei ZhouKe LinLiangmin FuFei LiuHansen LinYuhang ChenBowen ZhuangHui Liang Qiong DengZhu WangWei ChenJunhang LuoJiazheng CaoPengju Li

Published in: Journal of inflammation research (2023)

Through a systematic and comprehensive pan-cancer analysis, we demonstrated that overexpression of TREM1 in tumors correlated closely with unfavorable outcome, infiltration of immune-suppressive cells, and immune regulation, which highlights its potential use as a tumor prognostic biomarker and a novel target for immunotherapy.

Keyphrases

papillary thyroid
squamous cell
cell proliferation
induced apoptosis
stem cells
transcription factor
cell cycle arrest
signaling pathway
lymph node metastasis
squamous cell carcinoma
oxidative stress
young adults