Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese.
Masayuki SakiyamaHirotaka MatsuoHirofumi NakaokaYusuke KawamuraMakoto KawaguchiToshihide HigashinoAkiyoshi NakayamaAiri AkashiJun UeyamaTakaaki KondoKenji WakaiYutaka SakuraiKen YamamotoHiroshi OoyamaNariyoshi ShinomiyaPublished in: BMC medical genetics (2018)
BCAS3 is a coactivator of estrogen receptor alpha, and the influence of estrogen to serum uric acid level is well known. Our present replication study, as did the previous gout GWAS, demonstrated the common variant of BCAS3 to be associated with gout susceptibility.